Implications of ventricular arrhythmia vulnerability during murine electrophysiology studies.

Automated vulnerability testing identifies patients with inadequate defibrillation safety margin.

BACKGROUND Implantable cardioverter-defibrillator system efficacy is tested at implant by induction of ventricular fibrillation (VF). Defibrillation safety margin can be assessed without VF induction using upper limit of vulnerability methods, but these methods have required manual determination of T-wave timing. METHODS AND RESULTS To test the feasibility of an inductionless system of implan...

Local Anaesthesia Suppressing Idiopathic Ventricular Tachycardia: - A Cause of Non-inducible Arrhythmia During Electrophysiology Study

A 13 year old boy having idiopathic ventricular tachycardia had non-inducible tachycardia twice on electrophysiology (EP) study due to suppression of arrhythmia by local anaesthetic agent, lignocaine. This case report demonstrates a cause of non-inducibility or arrhythmia during EP study and effect of lignocaine in suppression of idiopathic ventricular tachycardia.

Ventricular arrhythmia vulnerability in cardiomyopathic mice with homozygous mutant Myosin-binding protein C gene.

BACKGROUND Homozygous mutant mice expressing a truncated form of myosin-binding protein C (MyBP-C(t/t)) develop severe dilated cardiomyopathy, whereas the heterozygous mutation (MyBP-C(t/+)) causes mild hypertrophic cardiomyopathy. Adult male MyBP-C(t/t) and MyBP-C(t/+) mice were evaluated for arrhythmia vulnerability with an in vivo electrophysiology study. METHODS AND RESULTS Surface ECGs w...

Response to letter regarding "Impact of local ablation on inter-connected channels within ventricular scar: mechanistic implications for substrate modification".

Spatial profiles of electrical mismatch determine vulnerability to conduction failure across a host-donor cell interface.

BACKGROUND Electrophysiological mismatch between host cardiomyocytes and donor cells can directly affect the electrical safety of cardiac cell therapies; however, the ability to study host-donor interactions at the microscopic scale in situ is severely limited. We systematically explored how action potential (AP) differences between cardiomyocytes and other excitable cells modulate vulnerabilit...